Introduction The successful transition of nurses from clinical practice to academia is essential to the training of a proficient future nursing workforce.However, deprived of requisite support and guidance, novice nurse educators often find the transition from bedside nursing practice to the classroom challenging and hence, adopt some coping strate
The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory
Histone deacetylases (HDACs) have been extensively studied as drug targets in neurodegenerative diseases, but less is known about their role in healthy neurons.We tested zinc-dependent HDACs using RNAi in Drosophila melanogaster and found memory deficits with RPD3 and HDAC6.We demonstrate that HDAC6 is required in both the larval and adult stages f
Development of a bispecific nanobody conjugate broadly neutralizes diverse SARS-CoV-2 variants and structural basis for its broad neutralization.
The continuous emergence of severe acute respiratory syndrome coronavirus rogue st pro 3 iron 2 (SARS-CoV-2) variants with increased transmissibility and profound immune-escape capacity makes it an urgent need to develop broad-spectrum therapeutics.Nanobodies have recently attracted extensive attentions due to their excellent biochemical and bindin